The important role of protamine in spermatogenesis and quality of sperm: A mini review

The important role of protamine in spermatogenesis and quality of sperm: A mini review

Blog Article

Objective: To prove that the decrease in the expression of protamine 2 affects the fertilization ability and the number of child production.Methods: During the development stage of elongating spermatids, human spermatozoa chromatin undergoes Pens a complex transition where histone is extensively replaced by protamine.Histone substitution by protamine 1 and 2 plays a significant role in condensing chromatin required to induce the quality of potent spermatozoa.The substitution also has a key role in protecting spermatozoa from effects of free radicals which can degrade the spermatozoa quality.Results: The results revealed that protamine deficiency instigated a severe disruption of spermatogenesis affecting male infertility.

In addition, the protamine expression disorder caused a decrease in number, motility, and morphology of spermatozoa.Conclusion: Our results of a study in mice confirmed that inhibin B injection caused a reduction in the expression of protamine 2 in cauda epididymis.It has implications in the decrease of motility, concentration, and spermatozoa viability hoodie so that it affects the fertilization ability and the number of child production.